Wernicke-Korsakoff Syndrome (WKS) is a neuro-degenerative disorder that is caused by a severe thiamine (vitamin B1) deficiency. Parts of the brain may be damaged as a result of this deficiency, causing increased difficulty with memory, movement, vision and coordination. Most cases of WKS result from heavy alcohol consumption over a long period of time. https://www.care partner.org/health-issues/wernicke-korsakoff-syndrome